Technology

FOREST Technologies

MatrixFOREST

PDF material is available upon request

Comprehensive profiling of RNA structure library vs compound library

RNA structure library / MotifBrew v.1

Komatsu R.K. et.al., Nature Communications, 2020.

MotifBrew is software that designs RNA structure libraries by extracting intracellularly validated or predicted RNA motifs from large-scale RNA datasets.

In this study, we integrated RNA structure libraries with microarray-based analysis to elucidate the binding properties of several RNA-binding proteins.

Link to paper

Our capabilities to optimize RNA-targeting drugs

Materials are available upon request

Affinity measurement of
RNA-drug interaction

Selectivity profiling 

In cell RNA structure probing

RNA-seq / Amplicon-seq

Collaboration (Drug discovery)

Our partnerships in drug discovery

Collaboration (Basic Research)

Comprehensive interaction analysis of RNA-binding small molecules / FID Assay

Nagasawa R. et.al., Communications Chemistry, 2024

This study used RNA structure libraries compatible with barcoded microarray to find high affinity RNA targets.


Link to paper

Related articles (Japanese)