Comprehensive profiling of RNA structure library vs compound library

• Profiling all combination of over 10,000 RNA motifs vs over 30,000 compounds.

• Binding site identification at single-nucleotide resolution 

• Sequencing-based analysis using linker-free detection of RNA-drug interaction

MotifBrew is software that designs RNA structure libraries by extracting intracellularly validated or predicted RNA motifs from large-scale RNA datasets.

In this study, we integrated RNA structure libraries with microarray-based analysis to elucidate the binding properties of several RNA-binding proteins.

Link to paper