Technology
Technology
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RNA-targeted small molecules screening
RNA-targeted small molecules screening
MatrixFOREST
MatrixFOREST
Comprehensive profiling of RNA structure library vs compound library
Profiling all combination of over 10,000 RNA motifs vs over 30,000 compounds.
Binding site identification at single-nucleotide resolution
Sequencing-based analysis using linker-free detection of RNA-drug interaction
Our capabilities to optimize RNA-targeting drugs
Our capabilities to optimize RNA-targeting drugs
SpliceVerse
SpliceVerse
Next generation platform for discovering splice regulator
Splicing Assay
Poison Exon Identification etc.
In cell RNA structure probing
and target engagement evaluation
In cell RNA structure probing
and target engagement evaluation
Our structure probing technique measures RNA structures directly in cells.
These methods enable not only high-resolution structural profiling but also evaluation of compound-dependent target engagement.
RNA-specialized analytics
RNA-specialized analytics
We offer xFOREST’s specialized RNA-focused experimental techniques as a fee-for-service platform.
Affinity Measurement
Selectivity Measurement
Selectivity profiling
by small-scale MatrixFOREST
Selectivity profiling
by small-scale MatrixFOREST
Affinity measurement of RNA-drug interaction
Affinity measurement of RNA-drug interaction
Collaboration (Drug discovery)
Collaboration (Drug discovery)
Our partnerships in drug discovery
Our partnerships in drug discovery
Collaboration (Academia)
Collaboration (Academia)
Comprehensive interaction analysis of RNA-binding small molecules / FID Assay
Comprehensive interaction analysis of RNA-binding small molecules / FID Assay
Nagasawa R. et.al., Communications Chemistry, 2024
This study used RNA structure libraries compatible with barcoded microarray to find high affinity RNA targets.
Related articles (Japanese)
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