Technology
FOREST Technologies
MatrixFOREST
PDF material is available upon request
Comprehensive profiling of RNA structure library vs compound library
Profiling all combination of over 10,000 RNA motifs vs over 30,000 compounds.
Binding site identification at single-nucleotide resolution
Sequencing-based analysis using linker-free detection of RNA-drug interaction
RNA structure library / MotifBrew v.1
Komatsu R.K. et.al., Nature Communications, 2020.
MotifBrew is software that designs RNA structure libraries by extracting intracellularly validated or predicted RNA motifs from large-scale RNA datasets.
In this study, we integrated RNA structure libraries with microarray-based analysis to elucidate the binding properties of several RNA-binding proteins.
Our capabilities to optimize RNA-targeting drugs
Materials are available upon request
Affinity measurement of
RNA-drug interaction
RNA-drug interaction
Selectivity profiling
In cell RNA structure probing
RNA-seq / Amplicon-seq
Collaboration (Drug discovery)
Our partnerships in drug discovery
Collaboration (Basic Research)
Comprehensive interaction analysis of RNA-binding small molecules / FID Assay
Nagasawa R. et.al., Communications Chemistry, 2024
This study used RNA structure libraries compatible with barcoded microarray to find high affinity RNA targets.
Related articles (Japanese)