Discovery engine
MatrixFOREST, SpliceVerse and SAR by Selectivity. Three technologies that take a program from hit finding through optimization.
INSPECT THE METHODS
RNA-TARGETED SMALL MOLECULES
RNA-targeted small molecules
xFOREST builds RNA-targeted small molecules against structured RNA. The discovery engine profiles RNA structure at scale, then redirects transcript fate through stability control, splicing control or poison exon inclusion.
The pages below open the methods, the library the engine screens, the three modes of action, and the papers that underwrite them.
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SELECT A DESTINATION
Chemical library
The compound library the engine multiplies against: more than 60,000 compounds selected for structured RNA, every generation chosen on the results of the last.
SEE WHAT GOES INOur target & MoA
Why structured RNA is addressable, and three ways to redirect its fate through stability, splicing or poison exon inclusion.
EXPLORE THE TARGET & MoAPublications
The platform was built in the open literature: multiplexed motif libraries, large-scale interaction analysis, variant-specific profiling and selective compound design.
VIEW THE PAPERS